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Sodium channel slow inactivation as a therapeutic target for myotonia congenita
OBJECTIVE: Patients with myotonia congenita have muscle hyperexcitability due to loss-of-function mutations in the chloride channel in skeletal muscle, which causes spontaneous firing of muscle action potentials (myotonia), producing muscle stiffness. In patients, muscle stiffness lessens with exerc...
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| Veröffentlicht in: | Ann Neurol |
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| Hauptverfasser: | , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2015
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4315705/ https://ncbi.nlm.nih.gov/pubmed/25515836 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ana.24331 |
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