An Efficient Strategy for Heterologous Expression and Purification of Active Peptide Hainantoxin-IV

Hainantoxin-IV (HNTX-IV) from the venom of the spider Selenocosmia hainana is a potent antagonist that specifically inhibits the tetrodotoxin-sensitive (TTX-S) sodium channels. The toxin peptide consists of 35 amino acids and adopts a typical inhibitory cystine knot (ICK) motif. To obtain adequate H...

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Veröffentlicht in:PLoS One
Hauptverfasser: Zhang, Hui, Huang, Peng-Fei, Meng, Er, Li, Wen-Ying, Zhou, Lu, Zhu, Ling-Yun, Wu, Lei, Li, Meng-Jie, Liang, Song-Ping, Zhang, Dong-Yi
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2015
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4315428/
https://ncbi.nlm.nih.gov/pubmed/25647561
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0117099
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