Conformational alteration of protein synthesis elongation factor EF-Tu by EF-Ts and by kirromycin.
Alterations of the structure of EF-Tu have been investigated by using the rate of EF-Tu cleavage by trypsin as a conformational probe. The presence of EF-Ts bound to EF-Tu results in a 10-fold increase in the cleavage rate. The antibiotic kirromycin, which inhibits protein synthesis by virtue of its...
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| Veröffentlicht in: | Proc Natl Acad Sci U S A |
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| Hauptverfasser: | , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
National Academy of Sciences
1977
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| Schlagworte: | |
| Online-Zugang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC431524/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/269389/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.74.8.3264 |
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