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Novobiocin and coumermycin inhibit DNA supercoiling catalyzed by DNA gyrase.

Novobiocin and coumermycin are known to inhibit the replication of DNA iing of DNA catalyzed by E. coli DNA gyrase, a recently discovered enzyme that introduces negative superhelical turns into covalently circular DNA. The activity of DNA gyrase purified from a coumermycin-resistant mutant strain is...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Gellert, M, O'Dea, M H, Itoh, T, Tomizawa, J
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 1976
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC431506/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/794878/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.73.12.4474
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