Novobiocin and coumermycin inhibit DNA supercoiling catalyzed by DNA gyrase.

Novobiocin and coumermycin are known to inhibit the replication of DNA iing of DNA catalyzed by E. coli DNA gyrase, a recently discovered enzyme that introduces negative superhelical turns into covalently circular DNA. The activity of DNA gyrase purified from a coumermycin-resistant mutant strain is...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Gellert, M, O'Dea, M H, Itoh, T, Tomizawa, J
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1976
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC431506/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/794878/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.73.12.4474
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