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Novobiocin and coumermycin inhibit DNA supercoiling catalyzed by DNA gyrase.

Novobiocin and coumermycin are known to inhibit the replication of DNA iing of DNA catalyzed by E. coli DNA gyrase, a recently discovered enzyme that introduces negative superhelical turns into covalently circular DNA. The activity of DNA gyrase purified from a coumermycin-resistant mutant strain is...

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Détails bibliographiques
Publié dans:Proc Natl Acad Sci U S A
Auteurs principaux: Gellert, M, O'Dea, M H, Itoh, T, Tomizawa, J
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 1976
Sujets:
Accès en ligne:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC431506/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/794878/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.73.12.4474
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