Novobiocin and coumermycin inhibit DNA supercoiling catalyzed by DNA gyrase.

Novobiocin and coumermycin are known to inhibit the replication of DNA iing of DNA catalyzed by E. coli DNA gyrase, a recently discovered enzyme that introduces negative superhelical turns into covalently circular DNA. The activity of DNA gyrase purified from a coumermycin-resistant mutant strain is...

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Main Authors: Gellert, M, O'Dea, M H, Itoh, T, Tomizawa, J
Format: Artigo
Jezik:Inglês
Izdano: 1976
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC431506/
https://ncbi.nlm.nih.gov/pubmed/794878
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