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In vitro treatment of HepG2 cells with saturated fatty acids reproduces mitochondrial dysfunction found in nonalcoholic steatohepatitis

Activity of the oxidative phosphorylation system (OXPHOS) is decreased in humans and mice with nonalcoholic steatohepatitis. Nitro-oxidative stress seems to be involved in its pathogenesis. The aim of this study was to determine whether fatty acids are implicated in the pathogenesis of this mitochon...

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Dettagli Bibliografici
Pubblicato in:Dis Model Mech
Autori principali: García-Ruiz, Inmaculada, Solís-Muñoz, Pablo, Fernández-Moreira, Daniel, Muñoz-Yagüe, Teresa, Solís-Herruzo, José A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Company of Biologists Limited 2015
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4314783/
https://ncbi.nlm.nih.gov/pubmed/25540128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.018234
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