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In vitro treatment of HepG2 cells with saturated fatty acids reproduces mitochondrial dysfunction found in nonalcoholic steatohepatitis

Activity of the oxidative phosphorylation system (OXPHOS) is decreased in humans and mice with nonalcoholic steatohepatitis. Nitro-oxidative stress seems to be involved in its pathogenesis. The aim of this study was to determine whether fatty acids are implicated in the pathogenesis of this mitochon...

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書目詳細資料
發表在:Dis Model Mech
Main Authors: García-Ruiz, Inmaculada, Solís-Muñoz, Pablo, Fernández-Moreira, Daniel, Muñoz-Yagüe, Teresa, Solís-Herruzo, José A.
格式: Artigo
語言:Inglês
出版: The Company of Biologists Limited 2015
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4314783/
https://ncbi.nlm.nih.gov/pubmed/25540128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.018234
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