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Partial genetic suppression of a loss-of-function mutant of the neuronal ceroid lipofuscinosis-associated protease TPP1 in Dictyostelium discoideum

Neuronal ceroid lipofuscinosis (NCL) is the most common childhood-onset neurodegenerative disease. NCL is inevitably fatal, and there is currently no treatment available. Children with NCL show a progressive decline in movement, vision and mental abilities, and an accumulation of autofluorescent dep...

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Bibliografische gegevens
Gepubliceerd in:Dis Model Mech
Hoofdauteurs: Phillips, Jonathan E., Gomer, Richard H.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: The Company of Biologists Limited 2015
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4314780/
https://ncbi.nlm.nih.gov/pubmed/25540127
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.018820
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