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Construction of pH-sensitive Her2-binding IgG1-Fc by directed evolution
For most therapeutic proteins, a long serum half-life is desired. Studies have shown that decreased antigen binding at acidic pH can increase serum half-life. In this study, we aimed to investigate whether pH-dependent binding sites can be introduced into antigen binding crystallizable fragments of...
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| Publicado no: | Biotechnol J |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
WILEY-VCH Verlag
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4314675/ https://ncbi.nlm.nih.gov/pubmed/24964247 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/biot.201300483 |
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