Construction of pH-sensitive Her2-binding IgG1-Fc by directed evolution

For most therapeutic proteins, a long serum half-life is desired. Studies have shown that decreased antigen binding at acidic pH can increase serum half-life. In this study, we aimed to investigate whether pH-dependent binding sites can be introduced into antigen binding crystallizable fragments of...

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Sparad:
Bibliografiska uppgifter
I publikationen:Biotechnol J
Huvudupphovsmän: Traxlmayr, Michael W, Lobner, Elisabeth, Hasenhindl, Christoph, Stadlmayr, Gerhard, Oostenbrink, Chris, Rüker, Florian, Obinger, Christian
Materialtyp: Artigo
Språk:Inglês
Publicerad: WILEY-VCH Verlag 2014
Ämnen:
Research Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4314675/
https://ncbi.nlm.nih.gov/pubmed/24964247
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/biot.201300483
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