High fat diet-induced modifications in membrane lipid and mitochondrial-membrane protein signatures precede the development of hepatic insulin resistance in mice

OBJECTIVE: Excess lipid intake has been implicated in the pathophysiology of hepatosteatosis and hepatic insulin resistance. Lipids constitute approximately 50% of the cell membrane mass, define membrane properties, and create microenvironments for membrane-proteins. In this study we aimed to resolv...

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Publicado en:Mol Metab
Autores principales: Kahle, M., Schäfer, A., Seelig, A., Schultheiß, J., Wu, M., Aichler, M., Leonhardt, J., Rathkolb, B., Rozman, J., Sarioglu, H., Hauck, S.M., Ueffing, M., Wolf, E., Kastenmueller, G., Adamski, J., Walch, A., Hrabé de Angelis, M., Neschen, S.
Formato: Artigo
Lenguaje:Inglês
Publicado: Elsevier 2014
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Original Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4314525/
https://ncbi.nlm.nih.gov/pubmed/25685688
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2014.11.004
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