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Tumor-targeting novel manganese complex induces ROS-mediated apoptotic and autophagic cancer cell death
In this study, the antitumor activity of the novel manganese (II) compound, Adpa-Mn {[(Adpa)Mn(Cl)(H(2)O)] (Adpa=bis(2-pyridylmethyl)amino-2-propionic acid)}, and its possible mechanisms of action were investigated. In vitro, the growth inhibitory effects of Adpa-Mn (with IC(50) values lower than 15...
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| Publié dans: | Int J Mol Med |
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| Auteurs principaux: | , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
D.A. Spandidos
2015
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4314420/ https://ncbi.nlm.nih.gov/pubmed/25604962 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ijmm.2015.2073 |
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