Therapeutic action of 5-HT(3) receptor antagonists targeting peritoneal macrophages in post-operative ileus

BACKGROUND AND PURPOSE: Post-operative ileus (POI) is induced by intestinal inflammation. Here, we aimed to clarify the effects of 5-HT(3) receptor antagonists against POI. EXPERIMENTAL APPROACH: We administered three 5-HT(3) receptor antagonists, ondansetron, tropisetron and palonosetron, to a mous...

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Bibliographic Details
Published in:Br J Pharmacol
Main Authors: Maehara, Toko, Matsumoto, Kenjiro, Horiguchi, Kazuhide, Kondo, Makoto, Iino, Satoshi, Horie, Shunji, Murata, Takahisa, Tsubone, Hirokazu, Shimada, Shoichi, Ozaki, Hiroshi, Hori, Masatoshi
Format: Artigo
Language:Inglês
Published: BlackWell Publishing Ltd 2015
Subjects:
Research Papers
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4314201/
https://ncbi.nlm.nih.gov/pubmed/25377620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13006
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