κ-opioid receptors are not necessary for the antidepressant treatment of neuropathic pain

BACKGROUND AND PURPOSE: Tricyclic antidepressants are used clinically as first-line treatments for neuropathic pain. Opioid receptors participate in this pain-relieving action, and preclinical studies in receptor-deficient mice have highlighted a critical role for δ-, but not μ-opioid receptors. In...

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Publicat a:Br J Pharmacol
Autors principals: Megat, Salim, Bohren, Yohann, Doridot, Stephane, Gaveriaux-Ruff, Claire, Kieffer, Brigitte L, Freund-Mercier, Marie-José, Yalcin, Ipek, Barrot, Michel
Format: Artigo
Idioma:Inglês
Publicat: BlackWell Publishing Ltd 2015
Matèries:
Research Papers
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4314193/
https://ncbi.nlm.nih.gov/pubmed/25297905
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12963
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