Biphasic modulation by mGlu(5) receptors of TRPV1-mediated intracellular calcium elevation in sensory neurons contributes to heat sensitivity

BACKGROUND AND PURPOSE: Elevation of glutamate, an excitatory amino acid, during inflammation and injury plays a crucial role in the reception and transmission of sensory information via ionotropic and metabotropic receptors. This study aimed to investigate the mechanisms underlying the biphasic eff...

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Bibliographic Details
Published in:Br J Pharmacol
Main Authors: Masuoka, T, Nakamura, T, Kudo, M, Yoshida, J, Takaoka, Y, Kato, N, Ishibashi, T, Imaizumi, N, Nishio, M
Format: Artigo
Language:Inglês
Published: BlackWell Publishing Ltd 2015
Subjects:
Research Papers
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4314192/
https://ncbi.nlm.nih.gov/pubmed/25297838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12962
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