Inhibition of oxidative metabolism leads to p53 genetic inactivation and transformation in neural stem cells

Alterations of mitochondrial metabolism and genomic instability have been implicated in tumorigenesis in multiple tissues. High-grade glioma (HGG), one of the most lethal human neoplasms, displays genetic modifications of Krebs cycle components as well as electron transport chain (ETC) alterations....

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Bartesaghi, Stefano, Graziano, Vincenzo, Galavotti, Sara, Henriquez, Nick V., Betts, Joanne, Saxena, Jayeta, Minieri, Valentina, A, Deli, Karlsson, Anna, Martins, L. Miguel, Capasso, Melania, Nicotera, Pierluigi, Brandner, Sebastian, De Laurenzi, Vincenzo, Salomoni, Paolo
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4313844/
https://ncbi.nlm.nih.gov/pubmed/25583481
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1413165112
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