Φορτώνει......
Loss of thymidine kinase 2 alters neuronal bioenergetics and leads to neurodegeneration
Mutations of thymidine kinase 2 (TK2), an essential component of the mitochondrial nucleotide salvage pathway, can give rise to mitochondrial DNA (mtDNA) depletion syndromes (MDS). These clinically heterogeneous disorders are characterized by severe reduction in mtDNA copy number in affected tissues...
Αποθηκεύτηκε σε:
| Κύριοι συγγραφείς: | , , , , , , , |
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| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
Oxford University Press
2010
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2850617/ https://ncbi.nlm.nih.gov/pubmed/20123860 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddq043 |
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