Haptoglobin phenotype predicts the development of focal and global cerebral vasospasm and may influence outcomes after aneurysmal subarachnoid hemorrhage

Cerebral vasospasm (CV) and the resulting delayed cerebral ischemia (DCI) significantly contribute to poor outcomes following aneurysmal subarachnoid hemorrhage (aSAH). Free hemoglobin (Hb) within the subarachnoid space has been implicated in the pathogenesis of CV. Haptoglobin (Hp) binds free pro-o...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Leclerc, Jenna L., Blackburn, Spiros, Neal, Dan, Mendez, Nicholas V., Wharton, Jeffrey A., Waters, Michael F., Doré, Sylvain
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2015
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4313833/
https://ncbi.nlm.nih.gov/pubmed/25583472
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1412833112
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