Haptoglobin phenotype predicts the development of focal and global cerebral vasospasm and may influence outcomes after aneurysmal subarachnoid hemorrhage

Cerebral vasospasm (CV) and the resulting delayed cerebral ischemia (DCI) significantly contribute to poor outcomes following aneurysmal subarachnoid hemorrhage (aSAH). Free hemoglobin (Hb) within the subarachnoid space has been implicated in the pathogenesis of CV. Haptoglobin (Hp) binds free pro-o...

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Bibliografski detalji
Izdano u:Proc Natl Acad Sci U S A
Glavni autori: Leclerc, Jenna L., Blackburn, Spiros, Neal, Dan, Mendez, Nicholas V., Wharton, Jeffrey A., Waters, Michael F., Doré, Sylvain
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2015
Teme:
Biological Sciences
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4313833/
https://ncbi.nlm.nih.gov/pubmed/25583472
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1412833112
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