Haptoglobin phenotype predicts the development of focal and global cerebral vasospasm and may influence outcomes after aneurysmal subarachnoid hemorrhage

Cerebral vasospasm (CV) and the resulting delayed cerebral ischemia (DCI) significantly contribute to poor outcomes following aneurysmal subarachnoid hemorrhage (aSAH). Free hemoglobin (Hb) within the subarachnoid space has been implicated in the pathogenesis of CV. Haptoglobin (Hp) binds free pro-o...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Leclerc, Jenna L., Blackburn, Spiros, Neal, Dan, Mendez, Nicholas V., Wharton, Jeffrey A., Waters, Michael F., Doré, Sylvain
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4313833/
https://ncbi.nlm.nih.gov/pubmed/25583472
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1412833112
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