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Impaired Hippo signaling promotes Rho1–JNK-dependent growth

The Hippo and c-Jun N-terminal kinase (JNK) pathway both regulate growth and contribute to tumorigenesis when dysregulated. Whereas the Hippo pathway acts via the transcription coactivator Yki/YAP to regulate target gene expression, JNK signaling, triggered by various modulators including Rho GTPase...

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Foilsithe in:Proc Natl Acad Sci U S A
Main Authors: Ma, Xianjue, Chen, Yujun, Xu, Wenyan, Wu, Nana, Li, Maoquan, Cao, Ying, Wu, Shian, Li, Qiutang, Xue, Lei
Formáid: Artigo
Teanga:Inglês
Foilsithe: National Academy of Sciences 2015
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4313816/
https://ncbi.nlm.nih.gov/pubmed/25583514
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1415020112
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