Overexpression of adenylyl cyclase type 5 (AC5) confers a proarrhythmic substrate to the heart

Inhibition of β-adrenergic receptor (β-AR) signaling is one of the most common therapeutic approaches for patients with arrhythmias. Adenylyl cyclase (AC) is the key enzyme responsible for transducing β-AR stimulation to increases in cAMP. The two major AC isoforms in the heart are types 5 and 6. Th...

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Détails bibliographiques
Publié dans:Am J Physiol Heart Circ Physiol
Auteurs principaux: Zhao, Zhenghang, Babu, Gopal J., Wen, Hairuo, Fefelova, Nadezhda, Gordan, Richard, Sui, Xiangzhen, Yan, Lin, Vatner, Dorothy E., Vatner, Stephen F., Xie, Lai-Hua
Format: Artigo
Langue:Inglês
Publié: American Physiological Society 2014
Sujets:
Cardiac Excitation and Contraction
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4312946/
https://ncbi.nlm.nih.gov/pubmed/25485900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00630.2014
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