Overexpression of adenylyl cyclase type 5 (AC5) confers a proarrhythmic substrate to the heart

Inhibition of β-adrenergic receptor (β-AR) signaling is one of the most common therapeutic approaches for patients with arrhythmias. Adenylyl cyclase (AC) is the key enzyme responsible for transducing β-AR stimulation to increases in cAMP. The two major AC isoforms in the heart are types 5 and 6. Th...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Am J Physiol Heart Circ Physiol
Main Authors: Zhao, Zhenghang, Babu, Gopal J., Wen, Hairuo, Fefelova, Nadezhda, Gordan, Richard, Sui, Xiangzhen, Yan, Lin, Vatner, Dorothy E., Vatner, Stephen F., Xie, Lai-Hua
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2014
Assuntos:
Cardiac Excitation and Contraction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4312946/
https://ncbi.nlm.nih.gov/pubmed/25485900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00630.2014
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados