Revisiting the ionic mechanisms of early afterdepolarizations in cardiomyocytes: predominant by Ca waves or Ca currents?

Early afterdepolarizations (EADs) have been implicated in severe cardiac arrhythmias and sudden cardiac deaths. However, the mechanism(s) for EAD genesis, especially regarding the relative contribution of Ca(2+) wave (CaW) vs. L-type Ca current (I(Ca,L)), still remains controversial. In the present...

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Bibliografiske detaljer
Main Authors: Zhao, Zhenghang, Wen, Hairuo, Fefelova, Nadezhda, Allen, Charelle, Baba, Akemichi, Matsuda, Toshio, Xie, Lai-Hua
Format: Artigo
Sprog:Inglês
Udgivet: American Physiological Society 2012
Fag:
Cardiac Excitation and Contraction
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3330805/
https://ncbi.nlm.nih.gov/pubmed/22307670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00742.2011
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