Revisiting the ionic mechanisms of early afterdepolarizations in cardiomyocytes: predominant by Ca waves or Ca currents?

Early afterdepolarizations (EADs) have been implicated in severe cardiac arrhythmias and sudden cardiac deaths. However, the mechanism(s) for EAD genesis, especially regarding the relative contribution of Ca(2+) wave (CaW) vs. L-type Ca current (I(Ca,L)), still remains controversial. In the present...

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Hlavní autoři: Zhao, Zhenghang, Wen, Hairuo, Fefelova, Nadezhda, Allen, Charelle, Baba, Akemichi, Matsuda, Toshio, Xie, Lai-Hua
Médium: Artigo
Jazyk:Inglês
Vydáno: American Physiological Society 2012
Témata:
Cardiac Excitation and Contraction
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3330805/
https://ncbi.nlm.nih.gov/pubmed/22307670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00742.2011
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