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Revisiting the ionic mechanisms of early afterdepolarizations in cardiomyocytes: predominant by Ca waves or Ca currents?

Early afterdepolarizations (EADs) have been implicated in severe cardiac arrhythmias and sudden cardiac deaths. However, the mechanism(s) for EAD genesis, especially regarding the relative contribution of Ca(2+) wave (CaW) vs. L-type Ca current (I(Ca,L)), still remains controversial. In the present...

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Autors principals: Zhao, Zhenghang, Wen, Hairuo, Fefelova, Nadezhda, Allen, Charelle, Baba, Akemichi, Matsuda, Toshio, Xie, Lai-Hua
Format: Artigo
Idioma:Inglês
Publicat: American Physiological Society 2012
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3330805/
https://ncbi.nlm.nih.gov/pubmed/22307670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00742.2011
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