Sorafenib synergizes with metformin in NSCLC through AMPK pathway activation

The multikinase inhibitor sorafenib is under clinical investigation for the treatment of many solid tumors, but in most cases, the molecular target responsible for the clinical effect is unknown. Furthermore, enhancing the effectiveness of sorafenib using combination strategies is a major clinical c...

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Bibliografiske detaljer
Udgivet i:Int J Cancer
Main Authors: Groenendijk, Floris H, Mellema, Wouter W, van der Burg, Eline, Schut, Eva, Hauptmann, Michael, Horlings, Hugo M, Willems, Stefan M, van den Heuvel, Michel M, Jonkers, Jos, Smit, Egbert F, Bernards, René
Format: Artigo
Sprog:Inglês
Udgivet: Blackwell Publishing Ltd 2015
Fag:
Cancer Therapy
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4312923/
https://ncbi.nlm.nih.gov/pubmed/25080865
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ijc.29113
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