N-Acetylcysteine improves mitochondrial function and ameliorates behavioral deficits in the R6/1 mouse model of Huntington's disease

Huntington's disease (HD) is a neurodegenerative disorder, involving psychiatric, cognitive and motor symptoms, caused by a CAG-repeat expansion encoding an extended polyglutamine tract in the huntingtin protein. Oxidative stress and excitotoxicity have previously been implicated in the pathoge...

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Detalhes bibliográficos
Publicado no:Transl Psychiatry
Main Authors: Wright, D J, Renoir, T, Smith, Z M, Frazier, A E, Francis, P S, Thorburn, D R, McGee, S L, Hannan, A J, Gray, L J
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4312826/
https://ncbi.nlm.nih.gov/pubmed/25562842
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/tp.2014.131
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