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Isolation, primary structure, and synthesis of α-endorphin and γ-endorphin, two peptides of hypothalamic-hypophysial origin with morphinomimetic activity

The isolation and primary structure of two peptides with morphinomimetic activity, obtained from an extract of porcine hypothalamus-neurohypophysis, are described. The amino acid sequence of the two peptides, named α-endorphin and γ-endorphin, was determined by mass spectrometry and densyl-Edman met...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Ling, Nicholas, Burgus, Roger, Guillemin, Roger
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 1976
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Online-Zugang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC431275/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1069261/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.73.11.3942
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