Two-site binding of C5a by its receptor: an alternative binding paradigm for G protein-coupled receptors.

The guanine nucleotide-binding protein-coupled receptor superfamily binds a vast array of biological messengers including lipids, odorants, catecholamines, peptides, and proteins. While some small molecules bind to these receptors at a single interhelical site, we find that the binding domain on the...

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Bibliografske podrobnosti
Main Authors: Siciliano, S J, Rollins, T E, DeMartino, J, Konteatis, Z, Malkowitz, L, Van Riper, G, Bondy, S, Rosen, H, Springer, M S
Format: Artigo
Jezik:Inglês
Izdano: 1994
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC43127/
https://ncbi.nlm.nih.gov/pubmed/8108389
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