Gut Microbiota-Dependent Trimethylamine N-oxide (TMAO) Pathway Contributes to Both Development of Renal Insufficiency and Mortality Risk in Chronic Kidney Disease

RATIONALE: Trimethylamine-N-oxide (TMAO), a gut microbial-dependent metabolite of dietary choline, phosphatidylcholine (lecithin) and L-carnitine, is elevated in chronic kidney diseases (CKD) and associated with coronary artery disease pathogenesis. OBJECTIVE: To both investigate the clinical progno...

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Publicado no:Circ Res
Main Authors: Wilson Tang, W. H., Wang, Zeneng, Kennedy, David J., Wu, Yuping, Buffa, Jennifer A., Agatisa-Boyle, Brendan, Li, Xinmin S., Levison, Bruce S., Hazen, Stanley L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4312512/
https://ncbi.nlm.nih.gov/pubmed/25599331
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.116.305360
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