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(+/-)-trans-7,8-dihydroxy-7,8-dihydrobenzo (a)pyrene: a potent skin carcinogen when applied topically to mice.

(+/-)-trans-7,8-Dihydroxy-7,8-dihydrobenzo[a]-pyrene, a known metabolite of benzo [a]pyrene, has been tested for carcinogenic activity on mouse skin by topical application of 0.15 or 0.30 mumol every 2 weeks for 60 weeks. At the low dose (0.15 mumol), the compound was equipotent to the parent hydroc...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Levin, W, Wood, A W, Yagi, H, Jerina, D M, Conney, A H
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1976
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC431245/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1069271/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.73.11.3867
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