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Predicting the excess solubility of acetanilide, acetaminophen, phenacetin, benzocaine, and caffeine in binary water/ethanol mixtures via molecular simulation

We present a general framework to predict the excess solubility of small molecular solids (such as pharmaceutical solids) in binary solvents via molecular simulation free energy calculations at infinite dilution with conventional molecular models. The present study used molecular dynamics with the G...

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Dades bibliogràfiques
Publicat a:J Chem Phys
Autors principals: Paluch, Andrew S., Parameswaran, Sreeja, Liu, Shuai, Kolavennu, Anasuya, Mobley, David L.
Format: Artigo
Idioma:Inglês
Publicat: AIP Publishing LLC 2015
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4312346/
https://ncbi.nlm.nih.gov/pubmed/25637996
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1063/1.4906491
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