Therapy with Plasma Purified Alpha1-Antitrypsin (Prolastin(®)) Induces Time-Dependent Changes in Plasma Levels of MMP-9 and MPO

The common Z mutation (Glu342Lys) of α1-antitrypsin (A1AT) results in the polymerization and intracellular retention of A1AT protein. The concomitant deficiency of functional A1AT predisposes PiZZ subjects to early onset emphysema. Clinical studies have implied that, among the biomarkers associated...

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Pubblicato in:PLoS One
Autori principali: Koepke, Janine, Dresel, Marc, Schmid, Severin, Greulich, Timm, Beutel, Björn, Schmeck, Bernd, Vogelmeier, Claus Franz, Janciauskiene, Sabina, Koczulla, Andreas Rembert
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2015
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4311911/
https://ncbi.nlm.nih.gov/pubmed/25635861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0117497
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