Therapy with Plasma Purified Alpha1-Antitrypsin (Prolastin(®)) Induces Time-Dependent Changes in Plasma Levels of MMP-9 and MPO

The common Z mutation (Glu342Lys) of α1-antitrypsin (A1AT) results in the polymerization and intracellular retention of A1AT protein. The concomitant deficiency of functional A1AT predisposes PiZZ subjects to early onset emphysema. Clinical studies have implied that, among the biomarkers associated...

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Detalles Bibliográficos
Publicado en:PLoS One
Main Authors: Koepke, Janine, Dresel, Marc, Schmid, Severin, Greulich, Timm, Beutel, Björn, Schmeck, Bernd, Vogelmeier, Claus Franz, Janciauskiene, Sabina, Koczulla, Andreas Rembert
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2015
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4311911/
https://ncbi.nlm.nih.gov/pubmed/25635861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0117497
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