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Protein design algorithms predict viable resistance to an experimental antifolate
Methods to accurately predict potential drug target mutations in response to early-stage leads could drive the design of more resilient first generation drug candidates. In this study, a structure-based protein design algorithm (K* in the OSPREY suite) was used to prospectively identify single-nucle...
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| I publikationen: | Proc Natl Acad Sci U S A |
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| Huvudupphovsmän: | , , , , , |
| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
National Academy of Sciences
2015
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4311853/ https://ncbi.nlm.nih.gov/pubmed/25552560 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1411548112 |
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