In vivo, Argonaute-bound microRNAs exist predominantly in a reservoir of low molecular weight complexes not associated with mRNA

MicroRNAs repress mRNA translation by guiding Argonaute proteins to partially complementary binding sites, primarily within the 3′ untranslated region (UTR) of target mRNAs. In cell lines, Argonaute-bound microRNAs exist mainly in high molecular weight RNA-induced silencing complexes (HMW-RISC) asso...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: La Rocca, Gaspare, Olejniczak, Scott H., González, Alvaro J., Briskin, Daniel, Vidigal, Joana A., Spraggon, Lee, DeMatteo, Raymond G., Radler, Megan R., Lindsten, Tullia, Ventura, Andrea, Tuschl, Thomas, Leslie, Christina S., Thompson, Craig B.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4311832/
https://ncbi.nlm.nih.gov/pubmed/25568082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1424217112
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