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First chemoenzymatic stereodivergent synthesis of both enantiomers of promethazine and ethopropazine
Enantioenriched promethazine and ethopropazine were synthesized through a simple and straightforward four-step chemoenzymatic route. The central chiral building block, 1-(10H-phenothiazin-10-yl)propan-2-ol, was obtained via a lipase-mediated kinetic resolution protocol, which furnished both enantiom...
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| Foilsithe in: | Beilstein J Org Chem |
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| Main Authors: | , , |
| Formáid: | Artigo |
| Teanga: | Inglês |
| Foilsithe: |
Beilstein-Institut
2014
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| Ábhair: | |
| Rochtain Ar Líne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4311712/ https://ncbi.nlm.nih.gov/pubmed/25670974 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3762/bjoc.10.322 |
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