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Spinal muscular atrophy: from tissue specificity to therapeutic strategies

Spinal muscular atrophy (SMA) is the most frequent genetic cause of death in infants and toddlers. All cases of spinal muscular atrophy result from reductions in levels of the survival motor neuron (SMN) protein, and so SMN upregulation is a focus of many preclinical and clinical studies. We examine...

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Detalhes bibliográficos
Publicado no:F1000Prime Rep
Main Authors: Iascone, Daniel M., Henderson, Christopher E., Lee, Justin C.
Formato: Artigo
Idioma:Inglês
Publicado em: Faculty of 1000 Ltd 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4311279/
https://ncbi.nlm.nih.gov/pubmed/25705387
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.12703/P7-04
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