Metabolism of benzo[a]pyrene: conversion of (+/-)-trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene to highly mutagenic 7,8-diol-9,10-epoxides.

Metabolites of (+/-)-trans 7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene formed by a rat liver microsomes and by a highly purified monoxygenase system were analyzed by high-pressure liquid chromatography. Four stereoisomeric tetraols of 7,8,9,10-tetrahydrobenzo[a]pyrene, known solvolysis products of the t...

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Bibliografiske detaljer

Udgivet i:	Proc Natl Acad Sci U S A
Principais autores:	Thakker, D R, Yagi, H, Lu, A Y, Levin, W, Conney, A H
Format:	Artigo
Sprog:	Inglês
Udgivet:	National Academy of Sciences 1976
Fag:	Research Article
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC431118/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1068451/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.73.10.3381
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