Phosphoinositide binding by the SNX27 FERM domain regulates its localization at the immune synapse of activated T-cells

Sorting nexin 27 (SNX27) controls the endosomal-to-cell-surface recycling of diverse transmembrane protein cargos. Crucial to this function is the recruitment of SNX27 to endosomes which is mediated by the binding of phosphatidylinositol-3-phosphate (PtdIns3P) by its phox homology (PX) domain. In T-...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:J Cell Sci
Autori principali: Ghai, Rajesh, Tello-Lafoz, Maria, Norwood, Suzanne J., Yang, Zhe, Clairfeuille, Thomas, Teasdale, Rohan D., Mérida, Isabel, Collins, Brett M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Company of Biologists 2015
Soggetti:
Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4311132/
https://ncbi.nlm.nih.gov/pubmed/25472716
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.158204
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi