A unique PDZ domain and arrestin-like fold interaction reveals mechanistic details of endocytic recycling by SNX27-retromer

The sorting nexin 27 (SNX27)-retromer complex is a major regulator of endosome-to-plasma membrane recycling of transmembrane cargos that contain a PSD95, Dlg1, zo-1 (PDZ)-binding motif. Here we describe the core interaction in SNX27-retromer assembly and its functional relevance for cargo sorting. C...

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Detalhes bibliográficos
Main Authors: Gallon, Matthew, Clairfeuille, Thomas, Steinberg, Florian, Mas, Caroline, Ghai, Rajesh, Sessions, Richard B., Teasdale, Rohan D., Collins, Brett M., Cullen, Peter J.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2014
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PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4156734/
https://ncbi.nlm.nih.gov/pubmed/25136126
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1410552111
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