PAS kinase is activated by direct SNF1-dependent phosphorylation and mediates inhibition of TORC1 through the phosphorylation and activation of Pbp1

We describe the interplay between three sensory protein kinases in yeast: AMP-regulated kinase (AMPK, or SNF1 in yeast), PAS kinase 1 (Psk1 in yeast), and the target of rapamycin complex 1 (TORC1). This signaling cascade occurs through the SNF1-dependent phosphorylation and activation of Psk1, which...

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Detalhes bibliográficos
Publicado no:Mol Biol Cell
Main Authors: DeMille, Desiree, Badal, Bryan D., Evans, J. Brady, Mathis, Andrew D., Anderson, Joseph F., Grose, Julianne H.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Cell Biology 2015
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4310746/
https://ncbi.nlm.nih.gov/pubmed/25428989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E14-06-1088
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