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Evaluation of a Dithiocarbamate Derivative as an Inhibitor of Human Glutaredoxin-1

CONTEXT: Glutaredoxins (GRX) are involved in the regulation of thiol redox state. GRX-1 is a cytosolic enzyme responsible for the catalysis of deglutathionylation of proteins. To date, very few inhibitors of GRX-1 have been reported. OBJECTIVE: The objective of this paper is to report 2-acetylamino-...

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Veröffentlicht in:J Enzyme Inhib Med Chem
Hauptverfasser: Sadhu, Satya S., Callegari, Eduardo, Zhao, Yong, Guan, Xiangming, Seefeldt, Teresa
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4310727/
https://ncbi.nlm.nih.gov/pubmed/22299579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3109/14756366.2011.649267
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