Stanniocalcin-1 Inhibits Renal Ischemia/Reperfusion Injury via an AMP-Activated Protein Kinase-Dependent Pathway

AKI is associated with increased morbidity, mortality, and cost of care, and therapeutic options remain limited. Reactive oxygen species are critical for the genesis of ischemic AKI. Stanniocalcin-1 (STC1) suppresses superoxide generation through induction of uncoupling proteins (UCPs), and transgen...

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Vydáno v:J Am Soc Nephrol
Hlavní autoři: Pan, Jenny Szu-Chin, Huang, Luping, Belousova, Tatiana, Lu, Lianghao, Yang, Yongjie, Reddel, Roger, Chang, Andy, Ju, Huiming, DiMattia, Gabriel, Tong, Qiang, Sheikh-Hamad, David
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Nephrology 2015
Témata:
Basic Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4310644/
https://ncbi.nlm.nih.gov/pubmed/25012175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2013070703
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