Oxidation of p53 through DNA Charge Transport Involves a Network of Disulfides within the DNA-Binding Domain

[Image: see text] Transcription factor p53 plays a critical role in the cellular response to stress stimuli. We have seen that p53 dissociates selectively from various promoter sites as a result of oxidation at long-range through DNA-mediated charge transport (CT). Here, we examine this chemical oxi...

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Bibliografski detalji
Izdano u:Biochemistry
Glavni autori: Schaefer, Kathryn N., Geil, Wendy M., Sweredoski, Michael J., Moradian, Annie, Hess, Sonja, Barton, Jacqueline K.
Format: Artigo
Jezik:Inglês
Izdano: American Chemical Society 2015
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4310631/
https://ncbi.nlm.nih.gov/pubmed/25584637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi501424v
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