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Oxidation of p53 through DNA Charge Transport Involves a Network of Disulfides within the DNA-Binding Domain
[Image: see text] Transcription factor p53 plays a critical role in the cellular response to stress stimuli. We have seen that p53 dissociates selectively from various promoter sites as a result of oxidation at long-range through DNA-mediated charge transport (CT). Here, we examine this chemical oxi...
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| Gepubliceerd in: | Biochemistry |
|---|---|
| Hoofdauteurs: | , , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
American
Chemical Society
2015
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| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4310631/ https://ncbi.nlm.nih.gov/pubmed/25584637 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi501424v |
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