The Role of the Mammalian DNA End-processing Enzyme Polynucleotide Kinase 3’-Phosphatase in Spinocerebellar Ataxia Type 3 Pathogenesis

DNA strand-breaks (SBs) with non-ligatable ends are generated by ionizing radiation, oxidative stress, various chemotherapeutic agents, and also as base excision repair (BER) intermediates. Several neurological diseases have already been identified as being due to a deficiency in DNA end-processing...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:PLoS Genet
Prif Awduron: Chatterjee, Arpita, Saha, Saikat, Chakraborty, Anirban, Silva-Fernandes, Anabela, Mandal, Santi M., Neves-Carvalho, Andreia, Liu, Yongping, Pandita, Raj K., Hegde, Muralidhar L., Hegde, Pavana M., Boldogh, Istvan, Ashizawa, Tetsuo, Koeppen, Arnulf H., Pandita, Tej K., Maciel, Patricia, Sarkar, Partha S., Hazra, Tapas K.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Public Library of Science 2015
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4310589/
https://ncbi.nlm.nih.gov/pubmed/25633985
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1004749
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