Cardioprotection by Controlling Hyperamylinemia in a “Humanized” Diabetic Rat Model

BACKGROUND: Chronic hypersecretion of the pancreatic hormone amylin is common in humans with obesity or prediabetic insulin resistance and induces amylin aggregation and proteotoxicity in the pancreas. We recently showed that hyperamylinemia also affects the cardiovascular system. Here, we investiga...

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Detalhes bibliográficos
Publicado no:J Am Heart Assoc
Main Authors: Despa, Sanda, Sharma, Savita, Harris, Todd R., Dong, Hua, Li, Ning, Chiamvimonvat, Nipavan, Taegtmeyer, Heinrich, Margulies, Kenneth B., Hammock, Bruce D., Despa, Florin
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2014
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4310392/
https://ncbi.nlm.nih.gov/pubmed/25146704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.114.001015
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