Cardioprotection by Controlling Hyperamylinemia in a “Humanized” Diabetic Rat Model

BACKGROUND: Chronic hypersecretion of the pancreatic hormone amylin is common in humans with obesity or prediabetic insulin resistance and induces amylin aggregation and proteotoxicity in the pancreas. We recently showed that hyperamylinemia also affects the cardiovascular system. Here, we investiga...

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Enregistré dans:
Détails bibliographiques
Publié dans:J Am Heart Assoc
Auteurs principaux: Despa, Sanda, Sharma, Savita, Harris, Todd R., Dong, Hua, Li, Ning, Chiamvimonvat, Nipavan, Taegtmeyer, Heinrich, Margulies, Kenneth B., Hammock, Bruce D., Despa, Florin
Format: Artigo
Langue:Inglês
Publié: Blackwell Publishing Ltd 2014
Sujets:
Original Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4310392/
https://ncbi.nlm.nih.gov/pubmed/25146704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.114.001015
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