Loss of TLR3 aggravates CHIKV replication and pathology due to an altered virus-specific neutralizing antibody response

RNA-sensing toll-like receptors (TLRs) mediate innate immunity and regulate anti-viral response. We show here that TLR3 regulates host immunity and the loss of TLR3 aggravates pathology in Chikungunya virus (CHIKV) infection. Susceptibility to CHIKV infection is markedly increased in human and mouse...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:EMBO Mol Med
Main Authors: Her, Zhisheng, Teng, Terk-Shin, Tan, Jeslin JL, Teo, Teck-Hui, Kam, Yiu-Wing, Lum, Fok-Moon, Lee, Wendy WL, Gabriel, Christelle, Melchiotti, Rossella, Andiappan, Anand K, Lulla, Valeria, Lulla, Aleksei, Win, Mar K, Chow, Angela, Biswas, Subhra K, Leo, Yee-Sin, Lecuit, Marc, Merits, Andres, Rénia, Laurent, Ng, Lisa FP
Formato: Artigo
Idioma:Inglês
Publicado em: BlackWell Publishing Ltd 2015
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4309666/
https://ncbi.nlm.nih.gov/pubmed/25452586
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.201404459
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados