Regions of focal DNA hypermethylation and long-range hypomethylation in colorectal cancer coincide with nuclear lamina–associated domains

Extensive changes in DNA methylation are common in cancer and may contribute to oncogenesis through transcriptional silencing of tumor-suppressor genes(1). Genome-scale studies have yielded important insights into these changes(2, 3, 4, 5) but have focused on CpG islands or gene promoters. We used w...

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Detalhes bibliográficos
Publicado no:Nat Genet
Main Authors: Berman, Benjamin P, Weisenberger, Daniel J, Aman, Joseph F, Hinoue, Toshinori, Ramjan, Zachary, Liu, Yaping, Noushmehr, Houtan, Lange, Christopher P E, van Dijk, Cornelis M, Tollenaar, Rob A E M, Van Den Berg, David, Laird, Peter W
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4309644/
https://ncbi.nlm.nih.gov/pubmed/22120008
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.969
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