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Regions of focal DNA hypermethylation and long-range hypomethylation in colorectal cancer coincide with nuclear lamina–associated domains
Extensive changes in DNA methylation are common in cancer and may contribute to oncogenesis through transcriptional silencing of tumor-suppressor genes(1). Genome-scale studies have yielded important insights into these changes(2, 3, 4, 5) but have focused on CpG islands or gene promoters. We used w...
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| Publicado no: | Nat Genet |
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| Main Authors: | , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4309644/ https://ncbi.nlm.nih.gov/pubmed/22120008 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.969 |
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