Intake of St John's wort improves the glucose tolerance in healthy subjects who ingest metformin compared with metformin alone

AIMS: Our objective was to investigate the steady-state pharmacokinetic and pharmacodynamic interaction between the antidepressive herbal medicine St John's wort and the antidiabetic drug metformin. METHODS: We performed an open cross-over study in 20 healthy male subjects, who received 1 g of...

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Bibliographische Detailangaben
Veröffentlicht in:Br J Clin Pharmacol
Hauptverfasser: Stage, Tore Bjerregaard, Pedersen, Rasmus Steen, Damkier, Per, Christensen, Mette Marie Hougaard, Feddersen, Søren, Larsen, John Teilmann, Højlund, Kurt, Brøsen, Kim
Format: Artigo
Sprache:Inglês
Veröffentlicht: BlackWell Publishing Ltd 2015
Schlagworte:
Drug Interactions
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4309635/
https://ncbi.nlm.nih.gov/pubmed/25223504
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.12510
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