Proteasomes, Sir2, and Hxk2 Form an Interconnected Aging Network That Impinges on the AMPK/Snf1-Regulated Transcriptional Repressor Mig1

Elevated proteasome activity extends lifespan in model organisms such as yeast, worms and flies. This pro-longevity effect might be mediated by improved protein homeostasis, as this protease is an integral module of the protein homeostasis network. Proteasomes also regulate cellular processes throug...

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Veröffentlicht in:PLoS Genet
Hauptverfasser: Yao, Yanhua, Tsuchiyama, Scott, Yang, Ciyu, Bulteau, Anne Laure, He, Chong, Robison, Brett, Tsuchiya, Mitsuhiro, Miller, Delana, Briones, Valeria, Tar, Krisztina, Potrero, Anahi, Friguet, Bertrand, Kennedy, Brian K., Schmidt, Marion
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2015
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4309596/
https://ncbi.nlm.nih.gov/pubmed/25629410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1004968
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