Brain Metastasis is Predetermined in Early-Stages of Cutaneous Melanoma by CD44v6 Expression through Epigenetic Regulation of the Spliceosome

Melanoma brain metastasis (MBM) is frequent and has a very poor prognosis with no current predictive factors or therapeutic molecular targets. Our study unravels the molecular alterations of cell-surface glycoprotein CD44 variants during melanoma progression to MBM. High expression of CD44 splicing...

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Detalhes bibliográficos
Publicado no:Pigment Cell Melanoma Res
Main Authors: Marzese, Diego M., Liu, Michelle, Huynh, Jamie L., Hirose, Hajime, Donovan, Nicholas C., Huynh, Kelly T., Kiyohara, Eiji, Chong, Kelly, Cheng, David, Tanaka, Ryo, Morton, Donald L., Barkhoudarian, Garni, Kelly, Daniel F., Hoon, Dave S.B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4309554/
https://ncbi.nlm.nih.gov/pubmed/25169209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/pcmr.12307
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