Ethnic-specific associations of rare and low-frequency DNA sequence variants with asthma

Common variants at many loci have been robustly associated with asthma but explain little of the overall genetic risk. Here we investigate the role of rare (<1%) and low-frequency (1–5%) variants using the Illumina HumanExome BeadChip array in 4,794 asthma cases, 4,707 non-asthmatic controls and...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Igartua, Catherine, Myers, Rachel A., Mathias, Rasika A., Pino-Yanes, Maria, Eng, Celeste, Graves, Penelope E., Levin, Albert M., Del-Rio-Navarro, Blanca E., Jackson, Daniel J., Livne, Oren E., Rafaels, Nicholas, Edlund, Christopher K., Yang, James J., Huntsman, Scott, Salam, Muhammad T., Romieu, Isabelle, Mourad, Raphael, Gern, James E., Lemanske, Robert F., Wyss, Annah, Hoppin, Jane A., Barnes, Kathleen C., Burchard, Esteban G., Gauderman, W. James, Martinez, Fernando D., Raby, Benjamin A., Weiss, Scott T., Williams, L. Keoki, London, Stephanie J., Gilliland, Frank D., Nicolae, Dan L., Ober, Carole
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Pub. Group 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4309441/
https://ncbi.nlm.nih.gov/pubmed/25591454
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms6965
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