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A pathogenic mutation in cytochrome c oxidase results in impaired proton pumping while retaining O(2)-reduction activity
In this work we have investigated the effect of a pathogenic mitochondrial DNA mutation found in human colon cells, at a functional-molecular level. The mutation results in the amino-acid substitution Tyr19His in subunit I of the human CytcO and it is associated with respiratory deficiency. It was i...
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| Pubblicato in: | Biochim Biophys Acta |
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| Autori principali: | , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2010
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4309374/ https://ncbi.nlm.nih.gov/pubmed/20117076 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbabio.2010.01.027 |
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