Elevated Estrogen Receptor-α in VHL-Deficient Condition Induces Microtubule Organizing Center Amplification via Disruption of BRCA1/Rad51 Interaction

Since loss of VHL is frequently detected early phase genetic event in human renal cell carcinoma, pVHL is assumed to be indispensable for suppression of tumor initiation step. However, induction of HIF-1α, target of pVHL E3 ligase, is more adequate to angiogenesis step after tumor mass formation. Co...

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Detalhes bibliográficos
Publicado no:Neoplasia
Main Authors: Jung, Youn-Sang, Chun, Ho-Young, Yoon, Min-Ho, Park, Bum-Joon
Formato: Artigo
Idioma:Inglês
Publicado em: Neoplasia Press 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4309251/
https://ncbi.nlm.nih.gov/pubmed/25499220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neo.2014.09.013
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