N-Acetylgalactosaminide α2,6-sialyltransferase II is a candidate enzyme for sialylation of galactose-deficient IgA1, the key autoantigen in IgA nephropathy

BACKGROUND: Galactose-deficient O-glycans in the hinge region (HR) of immunoglobulin A1 (IgA1) play a key role in the pathogenesis of IgA nephropathy (IgAN). O-Glycans of circulatory IgA1 consist of N-acetylgalactosamine (GalNAc) with a β1,3-linked galactose; both sugars may be sialylated. In patien...

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Detalhes bibliográficos
Publicado no:Nephrol Dial Transplant
Main Authors: Stuchlova Horynova, Milada, Vrablikova, Alena, Stewart, Tyler J., Takahashi, Kazuo, Czernekova, Lydie, Yamada, Koshi, Suzuki, Hitoshi, Julian, Bruce A., Renfrow, Matthew B., Novak, Jan, Raska, Milan
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2015
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Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4309194/
https://ncbi.nlm.nih.gov/pubmed/25281698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ndt/gfu308
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